Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease.

ABSTRACT:

Introduction

Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.

Methods

At 3 months old, App^NL-F mice received 4-vinylcyclohexene diepoxide (menopause model) or vehicle and were placed on a control (10% fat) or an HF diet (60% fat) until 10 months old.

Results

An interaction between HF diet and menopause led to impaired recognition memory. No effects of menopause were observed on amyloid pathology. However, menopause induced alterations in microglial response, white m

SUBMITTER: Abi-Ghanem C 

PROVIDER: S-EPMC11923387 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature