Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia.

ABSTRACT:

Abstract

Pediatric acute myeloid leukemia (pAML) is a clonal disease with recurrent genetic alterations that affect epigenetic states. However, the implications of epigenetic dysregulation in disease progression remain unclear. Here, we interrogated single-cell and clonal level chromatin accessibility of bone marrow samples from 28 patients with pAML representing multiple subtypes using mitochondrial single-cell assay for transposase-accessible chromatin with sequencing, which revealed distinct differentiation hierarchies and abnormal chromatin accessibility in a subtype-specific manner. Innate immune signaling was commonly enhanced across subtypes and related to improved advantage of clonal competition and unfavorable prognosis, with further reinforcement in a relapse-associated l

SUBMITTER: Cui B 

PROVIDER: S-EPMC11923433 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature