Metal Dyshomeostasis as a Driver of Gut Pathology in Autism Spectrum Disorders.

ABSTRACT: Despite being classified as neurodevelopmental disorders, in recent years, there has been a growing interest in the association between autism spectrum disorders (ASDs) and gut pathology. This comprehensive and systematic review explores a potential mechanism underlying gut pathology in ASDs, including alterations in gut microbiota, intestinal permeability, immune dysregulation, and gastrointestinal (GI) symptoms. Specifically, it delves into the role of toxic and essential metals and their interplay, affecting the development and function of the GI tract. The review also discusses the potential implications of this gut pathology in the development and management of ASDs. Studies have shown that heavy metal exposure, whether through environmental sources or dietary intake, can disrupt the

SUBMITTER: O'Grady K 

PROVIDER: S-EPMC11923526 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature