Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers' mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset.

Methods

Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-β levels and cognitive scores (word list recall).

Results

CPM mo

SUBMITTER: Tripathi V 

PROVIDER: S-EPMC11923559 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature