Using remote, digital, multi-day testing to characterize long-term forgetting in cognitively unimpaired older adults.

ABSTRACT:

Introduction

Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.

Methods

One hundred four cognitively unimpaired older adults completed a face-name memory task for seven consecutive days and were asked to recognize face-name pairs 1 week later. LTF was computed as the number of correctly identified stimuli divided by a participant's maximum performance during learning.

Results

Better learning was associated with less LTF (β = 0.52, 95% confidence interval [CI]:0.34-0.71, p < 0.001). Accelerated LTF was associated wit

SUBMITTER: Molinare CP 

PROVIDER: S-EPMC11923570 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature