The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center.

ABSTRACT:

Introduction

Alzheimer's disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular neuropathologies occur together. Previous studies have been limited by a large majority of participants with severe dementia or advanced stages of pathologies, which limits the detectability of cognitive effects from vascular neuropathologies.

Methods

Using neuropathology data from the National Alzheimer's Coordinating Center, we examined the association of vascular neuropathologies with cognitive scores in participants without severe dementia (N = 1526) using multivariable linear regression.

Results

Controlling for age, sex, education, LBD, and ADNC, arteriolosclerosis was associated with lower memory (β = -0.16 ± 0.06, p < 0.001), executive function (β = -0.25 ± 0.0

SUBMITTER: Hayes CA 

PROVIDER: S-EPMC11923572 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature