Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease.

ABSTRACT:

Introduction

Phenotype clustering reduces patient heterogeneity and could be useful when designing precision clinical trials. We hypothesized that the onset of early cognitive decline in patients would exhibit variance predicated on the clinical history documented prior to an Alzheimer's disease (AD) diagnosis.

Methods

Self-reported medical and substance use history (i.e., problem history) was used to cluster participants from the National Alzheimer's Coordinating Center (NACC) into distinct subtypes. Linear mixed effects modeling was used to determine the effect of problem history subtype on cognitive decline over 2 years.

Results

Two thousand seven hundred fifty-four individuals were partitioned into three subtypes: minimal (n = 1380), substance use (n = 1038), and

SUBMITTER: Mansel C 

PROVIDER: S-EPMC11923574 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature