Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and cognitive decline, associated with synaptic loss and degeneration of cholinergic neurons. New multitarget inhibitors for monoamine oxidase (MAO) and cholinesterase (ChE) enzymes are emerging as a potential treatment strategy for AD. Herein, we synthesized a series of N-benzyl-substituted biaryl phthalimide derivatives (3a-3m) encompassing potentially therapeutically active arenes/heteroarenes to serve as multitarget compounds for treating AD. To improve their binding affinity as well as inhibitory activity against ChE and MAO target proteins, comparable molecular structures were synthesized bearing electron-donating, electron-withdrawing, heterocyclic, and fluorinated moieties for a compreh

SUBMITTER: Abdullah N 

PROVIDER: S-EPMC11923636 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature