Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics.

ABSTRACT: Most neurons are influenced by multiple neuromodulatory inputs that converge on common effectors. Mechanisms that route these signals are key to selective neuromodulation but are poorly understood. G protein-gated inwardly rectifying K⁺ (GIRK or Kir3) channels mediate postsynaptic inhibition evoked by G protein-coupled receptors (GPCRs) that signal via inhibitory G proteins. GIRK-dependent signaling is modulated by Regulator of G protein Signaling proteins RGS6 and RGS7, but their selectivity for distinct GPCR-GIRK signaling pathways in defined neurons is unclear. We compared how RGS6 and RGS7 impact GIRK channel regulation by the GABA_B receptor (GABA_BR), 5HT_1A receptor (5HT_1AR), and A₁ adenosine receptor (A₁R) in

SUBMITTER: Luo H 

PROVIDER: S-EPMC11923652 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature