Assessing Toxicological Safety of EverX Posterior and Filtek Ultimate: An In-Depth Extractable and Leachable Study Under ISO 10993-17 and 10993-18 Standards.

ABSTRACT: This study critically evaluates the biocompatibility and toxicological safety of EverX Posterior (eXP) and Filtek Ultimate (FU) dental composites following the International Standardization Organization (ISO) 10993-17:2023 and 10993-18:2020 guidelines. Our research highlights important findings on the depth of cure, water absorption, solubility, and release profiles of organic compounds in these composites using advanced chromatographic techniques. The analysis revealed that both eXP and FU composites are safe for patients regarding extractable and leachable (E&L) compounds, indicating a low risk of adverse biological effects. It was found that eXP and FU had solubilities of 6.062 ± 0.576 and 0.864 ± 0.436 μg/mm³, respectively, revealing their stability and reliability for clini

SUBMITTER: Aydınoglu A 

PROVIDER: S-EPMC11923668 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature