Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study.

ABSTRACT:

Introduction

Neighborhood disadvantage has been shown to impact health and cognitive outcomes, while morphological similarity network (MSN) can elucidate structural morphological patterns underlying cognitive functions. We hypothesized MSNs could provide cortical patterns linked with neighborhood disadvantage and cognitive function, explaining the potential risk of cognitive impairment in disadvantaged neighborhoods.

Methods

For cognitively unimpaired participants from the Wisconsin Alzheimer's Disease Research Center or Wisconsin Registry for Alzheimer's Prevention (n = 524), and the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 100), neighborhood disadvantage was obtained using Area Deprivation Index (ADI) and its association with cognitive performance and

SUBMITTER: Safai A 

PROVIDER: S-EPMC11923708 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature