The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.

ABSTRACT: Major depressive disorder (MDD) is characterized by intercorrelated clinical symptoms and cognitive deficits, whose neural mechanisms in relation to these disturbances remain unclear. To elucidate this, we applied the relatively new approach of Network Control Theory (NCT), which considers how network topology informs brain dynamics based on white matter connectivity data. We used the NCT parameter of average controllability (AC) to assess the potential control that brain network nodes have on brain-state transitions associated with clinical and cognitive symptoms in MDD. DTI and high-resolution T1-weighted anatomical imaging were performed on 170 MDD patients (mean age 31.6 years; 72 males, 98 females) and 137 healthy controls (HC; mean age 33.4 years; 64 males, 73 females). We used an NC

SUBMITTER: Zhang A 

PROVIDER: S-EPMC11923719 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature