Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial.

ABSTRACT:

Background

Previous studies have shown that perioperative use of adjuvants, such as the alpha-2 agonist dexmedetomidine, may reduce postoperative pain and opioid requirements. However, information about optimal dosing is lacking. We investigated if premedication with intranasal dexmedetomidine compared with placebo reduces postoperative pain in patients undergoing total knee arthroplasty under spinal anaesthesia.

Methods

This single-centre, double-blind, two-arm study compared premedication with intranasal dexmedetomidine (single 1 μg kg^-1 dose) to intranasal saline in 101 consecutive elective patients undergoing total knee arthroplasty under spinal anaesthesia. The primary outcome was postoperative pain measured with the numerical rating scale during the first 24

SUBMITTER: Tiainen SM 

PROVIDER: S-EPMC11923756 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature