Prognostic implication of outpatient loop diuretic dose intensification trajectories in patients with chronic heart failure.

ABSTRACT:

Background

The relationship between outpatient oral loop diuretic (OLD) dose intensification trajectories and the prognosis of patients with chronic heart failure (CHF) remains unclear.

Methods

In 832 patients with CHF, OLD dose trajectories for 1 year were consecutively investigated. OLD dose intensification was defined as the first occurrence of OLD dose increase from the baseline within the first year. Patients were classified into three groups of OLD dose intensification trajectories: irreversible, reversible, and no intensification. Irreversible intensification was defined as an OLD dose intensification wherein the dose remained above the baseline during the first year of follow-up. Reversible intensification referred to an OLD dose intensification wherein the dose retu

SUBMITTER: Koike T 

PROVIDER: S-EPMC11923807 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature