Amyloid precursor protein promotes MASH progression by upregulating death receptor 6-mediated hepatocyte apoptosis.

ABSTRACT: Metabolic dysfunction-associated steatohepatitis (MASH) is a complicated process that contributes to end-stage liver disease and, eventually, hepatocellular carcinoma. Hepatocyte apoptosis, a well-defined form of cell death in MASH, is considered the primary cause of liver inflammation and fibrosis. However, the mechanisms underlying the regulation of hepatocyte apoptosis in MASH remain largely unclear. We explored the proapoptotic effect of hepatocyte amyloid precursor protein (APP) in MASH. C57BL/6J mice were fed a Western diet plus sugar water, a high-fat high-fructose diet, or a methionine and choline deficiency diet to induce MASH. APP expression was analyzed in murine MASH specimens. App^-/- mice and mice with adeno-associated virus-mediated APP overexpression were establis

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11923821 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature