Pathogenic mechanism of abnormal expression of HDAC3 in ovulatory granulosa cells inducing oocyte maturation disorder and its application in IVM.

ABSTRACT: Female reproductive health is troubled by oocyte maturation disorder. In mammals, granulosa cells (GCs) mediate luteinizing hormone (LH) action on oocyte maturation and ovulation. However, the pathogenesis of disordered GCs in oocyte maturation arrest is rarely studied. Our previous study has showed that HDAC3 (histone deacetylase 3) in GCs was decreased by LH at physiological conditions. Here, we observed significantly elevated HDAC3 levels in GCs from patients with oocyte maturation disorder following LH treatment compared with those with normal oocyte maturation. To clarify whether abnormally high levels of HDAC3 in ovulatory GCs resulted in female infertility, a mice model of GC-conditional overexpression of Hdac3 was constructed. The results showed that abnormally high levels of HDAC3

SUBMITTER: Wang H 

PROVIDER: S-EPMC11923827 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature