Bubble cloud-mediated cavitation for tumor mechanical ablation and effector immune cell deployment.

ABSTRACT: Histotripsy is a cavitation-based tumor ablation technology. To achieve precise cavitation-based ablation requires investigating the cavitation behavior of the bubble cloud and their impact on tumor tissue. This study explored the cavitation behavior of bubble clouds generated by perfluoropentane (PFP)-loaded nanodroplets and efficacy of bubble cloud cavitation in tumor ablation under varying ultrasound intensities. PFP-loaded nanodroplets (∼200 nm) were employed as exogenous cavitation nuclei to reducing the required ultrasound energy for activation of bubble cloud. We investigated the formation, vibration, and collapse of bubble clouds in solution and phantom models under varying ultrasound intensities. Results indicated distinct cavitation patterns: (1) Nanodroplets slowly vaporized and

SUBMITTER: Cao J 

PROVIDER: S-EPMC11923834 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature