Cross-Linked Cyclodextrin-Based Nanoparticles as Drug Delivery Vehicles: Synthesis Strategy and Degradation Studies.

ABSTRACT: In this work, we report on the synthesis and characterization of cyclodextrin-based nanocarriers, intended as new biogenic and biodegradable drug-delivery agents. Specifically, β-cyclodextrins were covalently cross-linked by carbonyl linkages using carbonyldiimidazole (CDI) and were colloidally stabilized via PEGylation to form β-CD-CO-PEG nanoparticles termed CD-CO NPs. The optimized synthesis results in size-controlled nanoparticles with a narrow particle size distribution and a hydrodynamic diameter around 200-300 nm in water and 100-160 nm as dried powder as observed by scanning electron microscopy. CD-CO nanoparticles are promising drug delivery carriers as they offer an intrinsic pore system originating from the β-cyclodextrin building units and an additional intraparticle pore space

SUBMITTER: Wehl L 

PROVIDER: S-EPMC11923844 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature