Synthesis, Characterization, and DFT Studies of NHC-Derived Amide-Functionalized Organoselenium Compounds.

ABSTRACT: The NHC-Se scaffold has emerged as an intriguing target, opening new avenues for discovering compounds that could significantly improve public health. Recently, extensive efforts have been made to synthesize NHC-Se-based organic compounds for various biomedical applications. Herein, we disclose a straightforward method to access a series of new N-heterocyclic carbene (NHC)-derived organoselenium molecules functionalized with an amide moiety. The parent NHC-Se adduct with a pendent ester moiety is sufficiently activated to facilitate a base- and additive-free ester-to-amide bond transformation. Furthermore, the use of PEG 3550, a biocompatible solvent, enhances reaction efficiency and simplifies the workup. This approach employs a broad spectrum of aliphatic amines with good function

SUBMITTER: Nawaz I 

PROVIDER: S-EPMC11923851 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature