Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes.

ABSTRACT: Construction of vinylsilane building blocks is important for advancing the synthesis of complex small molecules and natural products. Herein, we report a highly regio- and stereoselective copper-catalyzed hydrosilylation of unsymmetrical internal aryl alkynes. The reaction is performed across a broad scope of internal aryl alkynes, providing exclusive access to α-vinylsilane alkenyl arene products, including several silylated small molecule drug analogs.

SUBMITTER: Sloane SE 

PROVIDER: S-EPMC11923852 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature