Thyroid-Targeted Nano-Bombs Empower HIFU for Graves' Disease.

ABSTRACT: Graves' disease (GD) is an autoimmune disorder with a high incidence rate, particularly affecting women of reproductive age. Current treatment modalities for GD carry significant disadvantages, especially for pregnant or nursing women. As a novel extracorporeal therapeutic technique, high-intensity focused ultrasound (HIFU) shows great promise for treating GD; however, its low treatment efficacy impedes clinical application. In this study, a thyroid-targeted nano-bomb system (PD-PLGA@Si-Ab/PDA-I, PSAPI) is developed to enhance HIFU efficacy and improve therapeutic outcomes for GD. The core structure of PSAPI encapsulates a phase-transition material, perfluorohexane, and the anti-inflammatory drug diclofenac within a poly(lactide-co-glycolide) (PLGA) and silica shell. A polydopamine coating

SUBMITTER: Wang B 

PROVIDER: S-EPMC11923863 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature