Mitochondrial Protein MjEF-Tu is Secreted into Host Plants by Nematodes Eliciting Immune Signaling and Resistance.

ABSTRACT: Little is known about plant-parasitic animal-derived pathogen-associated molecular pattern (PAMP)/ pattern-recognition receptor (PRR) pairs. Additionally, mitochondrial proteins have not previously been reported to be secreted into hosts by pathogens. Here, it is found that the Meloidogyne javanica elongation factor thermo unstable (EF-Tu) (MjEF-Tu) located in the nematode mitochondria is up-regulated and secreted into the host plant during nematode parasitism. MjEF-Tu interacts with the PRR Arabidopsis thaliana EF-Tu receptor (AtEFR), triggering the plant hallmark defence responses mediated by AtEFR. An 18-aa sequence (Nelf18) in the N terminus of the nematode EF-Tu contributes to the immunogenic activity. M. javanica water extract and mitochondrial extract also induce plant immunity sens

SUBMITTER: Lin B 

PROVIDER: S-EPMC11923865 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature