Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts.

ABSTRACT: Vascular calcification is a highly regulated process in cardiovascular disease (CVD) and is strongly correlated with morbidity and mortality, especially in the adverse stage of vascular remodeling after coronary artery bypass graft surgery (CABG). However, the pathogenesis of vascular graft calcification, particularly the role of endothelial-smooth muscle cell interaction, is still unclear. To test how ECs interact with SMCs in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression. Unexpectedly, severe SMC calcification in artery grafts is found in TRIM35 conditional end

SUBMITTER: Leng Y 

PROVIDER: S-EPMC11923891 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature