Organizational Principles of the Primate Cerebral Cortex at the Single-Cell Level.

ABSTRACT: The primate cerebral cortex, the major organ for cognition, consists of an immense number of neurons. However, the organizational principles governing these neurons remain unclear. By accessing the single-cell spatial transcriptome of over 25 million neuron cells across the entire macaque cortex, it is discovered that the distribution of neurons within cortical layers is highly non-random. Strikingly, over three-quarters of these neurons are located in distinct neuronal clusters. Within these clusters, different cell types tend to collaborate rather than function independently. Typically, excitatory neuron clusters mainly consist of excitatory-excitatory combinations, while inhibitory clusters primarily contain excitatory-inhibitory combinations. Both cluster types have roughly equal numbe

SUBMITTER: Chen R 

PROVIDER: S-EPMC11923899 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature