Learning-associated astrocyte ensembles regulate memory recall.

ABSTRACT: The physical manifestations of memory formation and recall are fundamental questions that remain unresolved¹. At the cellular level, ensembles of neurons called engrams are activated by learning events and control memory recall^1-5. Astrocytes are found in close proximity to neurons and engage in a range of activities that support neurotransmission and circuit plasticity^6-10. Moreover, astrocytes exhibit experience-dependent plasticity^11-13, although whether specific ensembles of astrocytes participate in memory recall remains obscure. Here we show that learning events induce c-Fos expression in a subset of hippocampal astrocytes, and that this subsequently regulates the function of the hippocampal circuit in mice. Intersectional labelling of astr

SUBMITTER: Williamson MR 

PROVIDER: S-EPMC11924044 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature