White Matter Differences in Early-Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity.

ABSTRACT:

Background

Alcohol use disorder (AUD) is prevalent during young adulthood, and this risk may be linked to aberrations in neurodevelopmental processes. Prior studies examining white matter (WM) integrity in young adult individuals with AUD have shown considerable variability. This is due in part because traditional tensor related metrics such as fractional anisotropy are subject to limitations in estimation precision at sites of crossing or curving fibres. In response, to better understand differences in WM integrity of young adults with AUD, this study sought to uniquely employ two WM integrity measurement domains.

Methods

Twenty-five participants (n = 14 female) diagnosed with AUD and 33 social drinkers (n = 19 female) underwent structural and diffusion-weighted imaging. Di

SUBMITTER: Baker SK 

PROVIDER: S-EPMC11924133 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature