Chat GPT vs. Clinical Decision Support Systems in the Analysis of Drug-Drug Interactions.

ABSTRACT: The current standard method for the analysis of potential drug-drug interactions (pDDIs) is time-consuming and includes the use of multiple clinical decision support systems (CDSSs) and the interpretation by healthcare professionals. With the emergence of large language models developed with artificial intelligence, an interesting alternative arose. This retrospective study included 30 patients with polypharmacy, who underwent a pDDI analysis between October 2022 and August 2023, and compared the performance of Chat GPT and established CDSSs (MediQ®, Lexicomp®, Micromedex®) in the analysis of pDDIs. A multidisciplinary team interpreted the obtained results and decided upon clinical relevance and assigned severity grades using three categories: (i) contraindicated, (ii) severe, (iii) modera

SUBMITTER: Bischof T 

PROVIDER: S-EPMC11924163 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature