Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care.

ABSTRACT: Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy; five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.

SUBMITTER: Hui L 

PROVIDER: S-EPMC11924174 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature