Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer.

ABSTRACT:

Background

No curative therapy is currently available for metastatic prostate cancer (PCa). The diverse mechanisms of progression include fibroblast growth factor (FGF) axis activation.

Objective

To investigate the molecular and clinical implications of fibroblast growth factor receptor 1 (FGFR1) and its isoforms (α/β) in the pathogenesis of PCa bone metastases.

Design, setting, and participants

In silico, in vitro, and in vivo preclinical approaches were used. RNA-sequencing and immunohistochemical (IHC) studies in human samples were conducted.

Outcome measurements and statistical analysis

In mice, bone metastases (chi-square/Fisher's test) and survival (Mantel-Cox) were assessed. In human samples, FGFR1 and ladinin 1 (LAD1) analysis associated with PCa progre

SUBMITTER: Labanca E 

PROVIDER: S-EPMC11924198 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature