Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory.

ABSTRACT: The cerebellum is involved in higher-order cognitive functions, e.g., learning and memory, and is susceptible to age-related atrophy. Yet, the cerebellum's role in age-related cognitive decline remains largely unknown. We investigated cross-sectional and longitudinal associations between cerebellar volume and verbal learning and memory. Linear mixed effects models and partial correlations were used to examine the relationship between changes in cerebellum volumes (total cerebellum, cerebellum white matter [WM], cerebellum hemisphere gray matter [GM], and cerebellum vermis subregions) and changes in verbal learning and memory performance among 549 Baltimore Longitudinal Study of Aging participants (2,292 visits). All models were adjusted by baseline demographic characteristics (age, sex, ra

SUBMITTER: Cooper CP 

PROVIDER: S-EPMC11924273 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature