Bisignate Surface-Enhanced Raman Optical Activity with Analyte-Capped Colloids.

ABSTRACT: Spectroscopic detection of chiral compounds is often hampered by a low sensitivity. For Raman optical activity (ROA), the signal can be dramatically increased in surface-enhanced experiments. So far, however, reproducible surface-enhanced ROA (SEROA) spectra were obtained for a reporter molecule only via induced chirality, and the intensities were just proportional to the Raman scattering. In the present study, we show that the signal can be substantially increased if colloidal silver nanoparticles are prepared already in the presence of a chiral analyte. In this case, both the analyte's and reporter's bands are visible. In addition, some experiments provided bisignate SEROA patterns, thus significantly enhancing information about the molecular structure provided by this spectroscopic meth

SUBMITTER: Das M 

PROVIDER: S-EPMC11924305 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature