Considerations to forgo systemic treatment in patients with advanced esophageal or gastric cancer: A real-world evidence study.

ABSTRACT: The majority of patients with advanced esophageal or gastric cancer do not start palliative systemic treatment. To gain insight into the considerations underlying the decision not to start systemic treatment, we analyzed characteristics of patients starting and not starting systemic treatment, reasons for not starting systemic treatment, and receipt of local palliative treatments on a nationwide scale. Patients diagnosed with advanced esophageal or gastric cancer between 2015 and 2021 were included (n = 10,948). Survival was compared using propensity score matching on patient and disease characteristics. Most patients did not start systemic treatment (esophageal cancer 59%; gastric cancer 64%). These patients were generally older, more often female, had more comorbidities and a worse perfo

SUBMITTER: Slotman E 

PROVIDER: S-EPMC11924308 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature