Molecularly Imprinted Polyaniline-Coated Cu-Zeolitic Imidazolate Framework Nanoparticles: Uricase-Mimicking "Polynanozyme" Catalyzing Uric Acid Oxidation.

ABSTRACT: One of the drawbacks of nanozyme catalytic functions rests in their moderate catalytic activities due to the lack of effective binding sites concentrating the reaction substrate at the nanozyme catalytic interface. Methods to concentrate the substrates at the catalytic interface are essential to improving nanozyme functions. The present study addresses this goal by designing uric acid (UA) molecular-imprinted polyaniline (PAn)-coated Cu-zeolitic imidazolate framework (Cu-ZIF) nanoparticles as superior nanozymes, "polynanozymes", catalyzing the H₂O₂ oxidation of UA to allantoin (peroxidase activity) or the aerobic, uricase mimicking, oxidation of UA to allantoin (oxidase activity). While bare Cu-ZIF nanoparticles reveal only peroxidase activity and the nonimprinted PAn

SUBMITTER: Chen X 

PROVIDER: S-EPMC11924329 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature