Enriched knowledge representation in biological fields: a case study of literature-based discovery in Alzheimer's disease.

ABSTRACT:

Background

In Literature-based Discovery (LBD), Swanson's original ABC model brought together isolated public knowledge statements and assembled them to infer putative hypotheses via logical connections. Modern LBD studies that scale up this approach through automation typically rely on a simple entity-based knowledge graph with co-occurrences and/or semantic triples as basic building blocks. However, our analysis of a knowledge graph constructed for a recent LBD system reveals limitations arising from such pairwise representations, which further negatively impact knowledge inference. Using LBD as the context and motivation in this work, we explore limitations of using pairwise relationships only as knowledge representation in knowledge graphs, and we identify impacts of these limi

SUBMITTER: Pu Y 

PROVIDER: S-EPMC11924609 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature