Experimental orthodontic pain drives anxiety state through the induction of alterations to the neuronal architecture in hippocampus.

ABSTRACT:

Background

To explore the effect and mechanism of hippocampus on experimental orthodontic pain-induced anxiety.

Methods

Herein, we document a novel modeling method whereby the nickel-titanium (Ni-Ti) orthodontic wire was fixed stably in the oral cavity of mice with a ligation technique to induce stable distal movement of maxillary incisors to mimic orthodontic tooth movement. At the experimental endpoint, serum corticosterone assay, Golgi staining and Micro-CT were performed in each group after oral-facial mechanical pain sensitivity assessment and open field test.

Results

The mechanical pain sensitivity of experimental tooth movement pain (ETMP) mice had an apparent increased elicited following tooth movement. And anxiety-like behavior was developed: reduced the time

SUBMITTER: Que H 

PROVIDER: S-EPMC11924611 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature