Gut microbiota signatures in food allergy children without and with malnutrition: a cross-sectional study.

ABSTRACT:

Background

Altered gut microbiota (GM) profiles have been documented in children with food allergies (FA) and experiencing malnutrition. This study explored the GM composition in children with FA across varying degrees of malnutrition including those without malnutrition and those with different severity levels.

Methods

Fresh faecal samples were collected from 120 children aged 1-6 years, including 40 FA children with adequate weight (FANM), 40 FA children with malnutrition (FAM), and 40 healthy controls. The hypervariable region of the 16 S rDNA gene was subsequently sequenced to assess bacterial communities.

Results

Compared with healthy controls, the FANM group displayed a greater increase in the alpha diversity index. The FAM group exhibited an increase in seven g

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11924646 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature