Type 2 diabetes impacts DNA methylation in human sperm.

ABSTRACT:

Aims/hypothesis

Disorders of the reproductive system, including hypogonadism and reduced fertility, are an under-recognized complication of diabetes. Based on experimental data in mice, hyperglycemia and obesity may modify epigenetic marks in sperm and impact health and development of offspring, but data are more limited in humans. Thus, we sought to study the impact of type 2 diabetes and glycemic control on sperm quality and DNA methylation.

Methods

In this prospective cohort study, we recruited 40 men with BMI greater than 25 kg/m² including 18 with type 2 diabetes, 6 with prediabetes, and 16 normoglycemic controls. Assessments were repeated after 3 months in 9 men with type 2 diabetes and 7 controls. We analyzed reproductive hormones, sperm concentration and m

SUBMITTER: Su L 

PROVIDER: S-EPMC11924665 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature