Effects of different doses of ulinastatin on organ protection of deep hypothermic circulatory arrest in rats.

ABSTRACT:

Background

Deep hypothermic circulatory arrest (DHCA) can cause systemic inflammatory response (SIR) and ischemia-reperfusion (I/R) injury, potentially exacerbating organ failure. Ulinastatin (UTI) is a frequently employed anti-inflammatory medication in clinical practice, but different timing and dosage may influence its protective efficacy.

Methods

24 rats were randomly divided into four groups. Three different doses of UTI (3/10/30 × 10⁴ U/kg; low/medium/high dose) were administered in the DHCA rat model, with a control group that underwent DHCA without UTI administration. Inflammatory markers and routine clinical indicators of myocardial, hepatic, and renal tissue injury were evaluated. All rats underwent the standard DHCA procedure.

Results

Interleukin

SUBMITTER: Teng Y 

PROVIDER: S-EPMC11924670 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature