Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy.

ABSTRACT:

Background

Osteoarthritis (OA) is the most prevalent arthritic disease characterized by cartilage degradation and low-grade inflammation, for which there remains a lack of efficacious therapeutic interventions. Notably, mitigating the impact of oxidative stress (OS) and inflammatory factors could help alleviate or hinder the advancement of OA. Given the benefits of both quercetin (Que) and Magnesium ion (Mg²⁺) in OA treatment, coupled with the structural properties of Que, we have innovatively developed the Que-Mg²⁺ nanoparticles (NPs), aiming to deliver both Que and Mg²⁺ simultaneously and achieve enhanced therapeutic outcomes for OA. Moreover, to avoid the adverse reactions linked to frequent injections, sodium alginate (SA) microspheres encapsula

SUBMITTER: Chen J 

PROVIDER: S-EPMC11924703 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature