Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer.

ABSTRACT:

Background

Immunotherapy has significantly improved outcomes for cancer patients; however, its clinical benefits vary among patients and its efficacy across breast cancer subtypes remains unclear. To enhance immunotherapy efficacy, it is important to gain more insight into tumor-intrinsic immunomodulatory factors that could serve as therapeutic targets. We previously identified Lactate Dehydrogenase C (LDHC) as a promising anti-cancer target due to its role in regulating cancer cell genomic integrity. In this study, we investigated the effects of tumor LDHC expression on immune responses.

Methods

TIMER AND TIDE deconvolution methods were used to investigate the relationship between tumor LDHC expression, immune cell infiltration and T cell dysfunction. Multiplex cytokine ass

SUBMITTER: Naik A 

PROVIDER: S-EPMC11924725 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature