Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an elevated risk of cardiovascular conditions, such as lower extremity arterial disease (LEAD). The Fibrosis-4 (FIB-4) index, a non-invasive marker of liver fibrosis, may have predictive value for LEAD in patients with MASLD. This study aimed to explore the association between FIB-4 and LEAD in a cohort of patients with MASLD.

Methods

This cross-sectional study included 481 participants with MASLD, selected from a comprehensive health check-up database. Participants were categorized into three groups based on their FIB-4 index (< 1.3, 1.3-2.66, > 2.66) and underwent duplex ultrasonography to diagnose LEAD. Logistic regression models were employed to evaluate the association between

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11924756 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature