Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study.

ABSTRACT:

Background

Erythropoietin (EPO), a glycoprotein hormone primarily produced in the kidneys, plays pleiotropic roles in hematopoietic and non-hematopoietic system. However, the clinical relevance of circulating EPO in sepsis progression and outcomes remains contentious and requires further elucidation.

Methods

Participants were categorized into three groups on the basis of EPO tertiles. The primary outcome was 28-day mortality. Multivariate Cox proportional regression analysis and restricted cubic spline regression were employed to evaluate the association between EPO levels and 28-day mortality in sepsis patients. Subgroup analyses were also conducted. Causal mediation analysis was conducted to explore the potential mediating role of EPO in the relationship between lactate an

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11924785 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature