Fatty acid metabolism related gene MECR contributes to the progression of prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is the most common urological malignancy and second only to lung cancer in incidence among men. Its prognosis varies widely due to its heterogeneity. Research indicates that fatty acid metabolism may play a role in tumor development.

Methods

The gene expression profiles of PCa cell lines (GSE6919) in GEO database were analyzed to identify differentially expressed genes and their significance in relation to progression-free interval. The R package was employed to assess overall survival significance and clinicopathological features. The study investigated the effects of gene mutations and methylation on PCa and their correlation with immune cell infiltration in the tumor microenvironment, utilizing cBioPortal and UALCAN resources. TIMER was us

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11924791 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature