Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions.

ABSTRACT:

Background

The definition of sepsis-associated acute kidney injury (SA-AKI) was updated in 2023. This study aims to describe the epidemiology of SA-AKI using updated consensus definition and to evaluate clinical outcomes.

Methods

The study was a retrospective cohort analysis conducted at two academic medical centers. Adult patients admitted to intensive care units (ICU) between 2010 and 2022 were included and categorized as SA-AKI, sepsis alone, or AKI alone. SA-AKI was further classified by time of onset (early < 2 days from sepsis diagnosis vs. late 2-7 days following sepsis diagnosis) and presence of septic shock. Clinical outcomes included hospital mortality and major adverse kidney events (MAKE = death, kidney replacement therapy, or reduced kidney function from baselin

SUBMITTER: Takeuchi T 

PROVIDER: S-EPMC11924826 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature