Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis.

ABSTRACT:

Background

Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims to identify potential new therapeutic targets for CH through proteome-wide mendelian randomization (PWMR).

Methods

We used PWMR to estimate the causal effects of plasma proteins on CH. This analysis integrated plasma protein quantitative trait loci (pQTL) data with genome-wide association study (GWAS) results of CH phenotypes. In addition, we conducted various sensitivity analyses, enrichment analyses, phenome-wide MR assessments, protein-protei

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC11924832 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature