Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(sp²)-H Bond Functionalization.

ABSTRACT: Monoanionic, bidentate-auxiliary-directed, cobalt-catalyzed C-H bond functionalization has become a very useful tool in organic synthesis. A comprehensive investigation into isolated organometallic intermediates and their reactivity within the catalytic cycle is lacking. We report here mechanistic studies of cobalt-catalyzed, aminoquinoline-directed C(sp²)-H bond functionalization. A number of organometallic Co(III) intermediates have been isolated and structurally characterized, including, for the first time in the aminoquinoline system, complexes arising from migratory insertion into cobalt-carbon bonds. The catalytic and stoichiometric reactions of cobalt(III) aryls with alkenes, alkynes, carbon monoxide, cyclic secondary amines, and aminoquinoline benzamides have been explor

SUBMITTER: Lukasevics L 

PROVIDER: S-EPMC11924839 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature