Association of the tumor microenvironment collagen score and immunoscore with colon cancer lymph node metastasis.

ABSTRACT:

Background

In clinical practice, lymph node status has an important impact on colon cancer (CC) management and treatment. The role of the tumor microenvironment collagen score and immunoscore in colon cancer lymph node metastasis remains unknown.

Methods

A total of 249 CC patients who underwent laparoscopic-assisted D3 lymphadenectomy from June 2016 to May 2019 were included. The patients' clinicopathological data were collected retrospectively. A total of 142 collagen features were extracted by multiphoton imaging and collagen quantification. A collagen score was constructed using a LASSO logistic regression model. Antibodies against CD3 and CD8 were used for immunostaining. The immunoscore was constructed based on the mean densities of CD3 + and CD8 + T cells both in the t

SUBMITTER: Long C 

PROVIDER: S-EPMC11924846 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature