Epigenetic Regulation of CD8⁺ Effector T Cell Differentiation by PDCD5.

ABSTRACT: Epigenetic modification plays a crucial role in establishing the transcriptional program that governs the differentiation of CD8⁺ effector T cells. However, the mechanisms by which this process is regulated at an early stage, prior to the expression of master transcription factors, are not yet fully understood. In this study, we have identified PDCD5 as an activation-induced molecule that is necessary for the proper differentiation and expansion of antigen-specific CD8⁺ effector T cells in a mouse model of chronic viral infection. The genetic deletion of Pdcd5 resulted in impaired differentiation and function of effector T cells, while T-cell activation, metabolic reprogramming, and the differentiation of memory/exhausted T cells were largely unaffected. At the molecu

SUBMITTER: Jin L 

PROVIDER: S-EPMC11924876 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature