Treatment rechallenge is safe and leads to better survival in pancreatic cancer patients with interstitial pneumonitis.

ABSTRACT:

Background and aims

Interstitial pneumonitis is a potentially fatal complication of cancer-related therapy. However, data regarding the risk factors, prognosis and safety and benefit of rechallenge treatment are scarce.

Methods

Patients diagnosed with pancreatic cancer were retrospectively enrolled, and those with pneumonitis were identified. We investigated the incidence and etiology of pneumonitis, potential risk factors, and impact of treatment rechallenge on clinical outcomes.

Results

A total of 809 patients were diagnosed with pancreatic cancer, among whom 62 (7.7%) were diagnosed with interstitial pneumonitis. Risk factors identified through competing risk analysis included nab-paclitaxel, gemcitabine, erlotinib, and previous lung diseases such as pre-existing I

SUBMITTER: Yu HY 

PROVIDER: S-EPMC11924909 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature