Photoradiolabeling of onartuzumab with ^99mTc and ¹⁸⁸Re-tricarbonyl for radiotheranostics of gastric cancer.

ABSTRACT: The clinically relevant nuclear isomer of technetium-99 (^99mTc) and the radionuclides rhenium-186/188 (¹⁸⁶Re and ¹⁸⁸Re) represent an almost ideal match for the development of radiotracers for applications in diagnostic imaging and molecularly targeted radionuclide therapy. Although the chemistry of Tc and Re is similar, important differences arise in both the synthesis and properties of their complexes. Here, we report the synthesis and characterization of ^99mTc- and ¹⁸⁸Re-onartuzumab by labeling of the cancer-specific mAb onartuzumab (MetMAb) with the corresponding metal-tricarbonyl complexes derived from a novel photoactivatable ligand. The acyclic tris-amine ligand L1, featuring a photoactive aryl azide (ArN₃) grou

SUBMITTER: Genz J 

PROVIDER: S-EPMC11924949 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature